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A controlled release system can extend exposure after a single administration and can drastically reduce the number of injections.[] Amino acids and small peptides are not themselves immunogenic, but macromolecular proteins are often recognized as foreign by the body, which may respond with the production of a specific antibody

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Moreover, the magnitude of this effect significantly depended on the dosage: median time to death, or ventilation support, was 570 days for placebo, 1,087 days for 25 mg, and 1,197 days for 50 mg methylcobalamin groups

But will it stick?"